nSTRIDE® is an Autologous (from your own body) Anti-Inflammatory treatment, which is designed to treat joint pain associated with knee osteoarthritis. In laboratory testing, nSTRIDE® has been shown to protect cartilage tissue. This protective quality may slow the progression of osteoarthritis as well.4^
nSTRIDE® will be administered directly in the knee joint. Positive outcomes are possible due to the presence of high concentrations of anti-inflammatory proteins.16
These “good” proteins may help stimulate a biologic cascade, which has been shown to block cartilage destruction in osteoarthritis.4^ The pain in the joint may be reduced, and the joint function may be improved. The treatment is designed to be a single injection therapy in the doctor’s office.
The nSTRIDE® Kit processes the patient’s own blood in the clinic to concentrate white blood cells, platelets and plasma proteins into a small volume of plasma. The output is approximately 2 to 3cc of anti-inflammatory solution.
You may experience side effects (e.g. bruising, local pain or swelling) associated with the blood draw, knee injection, MRI or X-ray procedures.
There is no cure for OA.15 But successful treatment with nSTRIDE® may reduce or relieve your pain, which may increase your mobility and comfort.3 Your osteoarthritis may not improve or may get worse.
nSTRIDE® may significantly decrease or eliminate pain, reduce stiffness and help restore mobility and flexibility.1,3,14*
Pain relief may be expected after one to two weeks.3,14*
Yes. Studies have demonstrated the safety of nSTRIDE®.3
It is recommended that you minimise your activity level for 14 days and not exceed pre-injection activity levels.
Based on preclinical and early clinical results, patients may expect to see benefits for up to 24-36 months.1,2,3,14*
Patients with mild to moderate knee osteoarthritis can receive the nSTRIDE® treatment.
Clinical studies have demonstrated the effectiveness of one treatment. These studies suggest one injection can last up to 24-36 months.1,2,3*
The injection can be given in a clinic room designated by your clinician. This is usually somewhere in a hospital or medical facility.
Find your closest nSTRIDE® clinic and book a consultation to see if nSTRIDE® is right for you.
2-3 cc of final output will be injected directly in the knee joint.
The nSTRIDE® Procedure
Your local nSTRIDE® clinic takes your blood and we harvest the white blood cells from it. Within 20 minutes blood is processed to make anti-inflammatory proteins. Your local nSTRIDE® clinic injects those proteins back into your joint. Your pain is reduced, your mobility and your disease progression might slow down.
Yes. Your family can attend with you. Your clinician may ask for a limited number or that family members stay outside the room while taking blood samples or during treatment for certain reasons, such as infection policies at the clinical site, but this can be discussed with your clinician.
INDICATIONS FOR USE
The nSTRIDE APS System including ACD-A is designed to be used for the safe and rapid preparation of autologous protein solution (APS) from a small sample of blood at the patient’s point of care. Health care professionals use the nStride APS System to mitigate symptoms of knee osteoarthritis such as pain and inflammation.
CONTRAINDICATIONS
POSSIBLE ADVERSE EFFECTS FROM BLOOD DRAW AND INTRA-ARTICULAR INJECTION
DISCLOSURE OF RESIDUAL RISKS:
While complications and side effects vary depending on the type of orthopedic surgery and while mitigations are implemented to reduce these risks as far as possible, some residual risks, associated with this system, that can arise during and following surgery include:
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^ Laboratory studies are not necessarily indicative of clinical outcomes
* As measured by WOMAC pain scores reported by patients continuing follow-up through 3 years (n = 19).
19 out of the original cohort of 31.
*Results are not necessarily typical, indicative, or representative of all recipient patients. Results will vary due to health, weight, activity and other variables. Not all patients are candidates for this product and/or procedure. Only a medical professional can determine the treatment appropriate for your specific condition.
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